New weight loss medications like Ozempic®, Wegovy®, Mounjaro®, and Zepbound® (known as GLP-1s) can help you lose weight, but research shows that without a plan, the weight almost always comes back if the prescription ends. Losing the Weight Loss Meds is the first playbook designed specifically to help you transition off medication — and keep your hard-earned success for life.
Written by leading obesity experts Dr. Holly R. Wyatt and Dr. James O. Hill, Losing the Weight Loss Meds lays out a science- backed, 10-week program to replace medication with the power of food, physical activity, and mindstate. You’ll discover how
Reset your appetite naturally with smart food strategies Use physical activity to restore and optimize metabolism Strengthen your mindstate to build resilience against cravings and setbacks Catch early signs of weight regain and stop it before it snowballs Create routines and environments that make success easier to sustain
This isn’t another quick-fix diet. It’s a practical guide for the moment millions of people now life after GLP-1s.
Whether you’re preparing to stop medication now or later, or just beginning your weight loss journey, this playbook equips you with the tools to protect your progress and fully live the life you’ve worked so hard to create.
What are weight loss medications designed to do? Simply put, help people lose weight—a lifelong struggle for many. Weight loss brings significant health benefits, from improved heart health to reduced risk of diabetes and less strain on joints affected by arthritis. For me, however, this journey has spanned more than 40 years and includes a long battle with morbid obesity.
GLP-1 medications are not the only path to weight loss, nor are they a magic solution. Still, with the rise of medications such as Wegovy, Mounjaro, and others, many people—both men and women—are left wondering about the end game. Are these medications meant to be taken indefinitely, or does stopping them inevitably lead to weight regain? The answer, as this book makes clear, varies from person to person. Dosage and duration differ widely, and no self-help or health-related book can replace working closely with one’s doctor. That partnership is essential.
My own experience includes trying numerous approaches, from Weight Watchers to weight loss surgery, yet my weight has remained difficult to manage. While increased physical activity and exercise are undeniably part of the bigger picture, for some of us, a sedentary lifestyle is not rooted in laziness but in serious medical issues that complicate movement and activity.
In Losing the Weight Loss Meds, Drs. Wyatt and Hill present a thoughtful ten-week playbook for individuals preparing to come off weight loss medications and facing the very real fear of stopping something that works. For me, that fear borders on obsession—I never want to return to my heaviest weight. This book emphasizes preparation, including the possibility of working with a therapist before beginning the transition off medication.
The guide is divided into three parts: Understanding the Game, The Transition Playbook, and Mastering the Long Game. Along the way, the authors introduce practical concepts such as “pie on the plate versus pie in the sky,” managing “food noise,” understanding metabolism, and finding a personalized plan that works long-term. The focus throughout is on realistic, proven strategies designed to help readers succeed beyond medication.
This is an excellent, compassionate guide filled with practical suggestions that I will seriously consider when the day comes that my doctor—or my insurance—discontinues this medication. While it is just one step in a much larger journey, it is an important one. I hope this book helps other readers and listeners navigate the weeks, months, and years ahead with confidence and preparation.
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